量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Bone metastases occur in up to 70% of breast or prostate cancer patients and in about 15% to 30% of other cancer patients (lung, stomach, uterus, bladder, colon, thyroid, kidney, and rectum).1 Early detection of metastatic bone disease and the definition of the extent, pattern, and aggressiveness are important prerequisites for adequate treatment by resection, radiation, or systemic therapy.2,3 Medical
imaging techniques play an important role in the assessment of these bone metastases. A wealth of historical data and clinical experience led to the establishment of the isotope bone scan as the reference standard in the search for skeletal metastatic disease. However, in malignancies, bone scans are now used less often and are not considered routine in all cases of breast or prostate cancer. Essentially, bone scans are currently used only where there is an issue regarding staging or if the patient has bone symptoms.5,6 The most commonly used tracer for skeletal imaging in general nuclear medicine is 99mTc-Methylene diphosphonate (99mTc-MDP).7 Amino acid metabolism of cancer is associated with numerous catabolic processes favoring tumor growth.8 As an essential amino acid, L-methionine plays a central role in the altered metabolism of cancer cells.9 Increased uptake of MET as measured by PET has been suggested to reflect increased transport, transmethylation rate, and protein synthesis of malignant tissue.10-12 In this study, we evaluated the role of whole body (WB) PET 11C-Methionine imaging in the detection of skeletal
metastatic lesions in comparison to bone scintigraphy being the conventional screening method for bone metastasis.
Whole Body Methionine PET vs. Conventional Bone Scintigraphy for Early Detection of Metastatic Bone Lesions
