量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Cancer patients vary considerably in normal tissue reactions after radiotherapy. It has been hypothesized that the clinical radiosensitivity of normal tissues should be regarded as a so-called complex trait dependent on the cumulative effect of many minor genetic determinants. To identify markers for these determinants, single nucleotide polymorphism (SNP) markers were typed for the candidate genes which were determined by mainly our gene expression analyses. We have investigated genotypes of more than three hundreds individuals consisting of breast cancer, ovarian cancer and prostate cancer patients. Statistical analysis indicated that the SNP types on, at least 12 genes were associated with the radiation-induced adverse effects.
正常組織障害における放射線感受性遺伝子研究−遺伝子多型からのアプローチー
