量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Radiation induced pneumonitis and consequential pulmonary fibrosis are known serious side effects after thoracic radiation therapy. Since these side effects act as a dose-limiting factor, understanding the molecular and pathogenic mechanisms underlying these symptoms is essential for improvement of radiotherapy, including heavy ion radiotherapy.
In this study, we aim to identify molecular mechanisms, which can become novel target for prevention or treatment of radiation induced pneumonitis and pulmonary fibrosis. C3H/He, C57BL/6J and C3B6F1 mice were locally irradiated in the thorax by carbon-ion beam (290MeV/n), and subsequently we performed histological analyses of the lung at different time points after irradiation.
Previously our study showed pneumonitis and consequential pulmonary fibrosis developed 5-6 months after irradiation. Due to the fact that less than 5 months have passed since our first dose of radiation (2011.9.27), we are currently observing the pathological changes. We will report our results next year.
重粒子線照射による肺晩発障害機構の解明
