量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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We have studied repair or recover from cell damages produced heavy-ion irradiation using animals and cultured mammalian cells. Relationship between the acquisition of radioresistance and fractionated irradiation was studied in vivo mice crypt cell survival. The acquisition of radioresistance was suppressed by injection of bFGF antibody before irradiation, and induction of bFGF-R was increased after the 3rd or 11th irradiation in the fractionated irradiation. Kinetics of SLDR and LET dependency of PLDR were studied with in vitro culture cell survival. The SLDR kinetics was observed with split irradiation at the middle position of carbon 6-cm SOBP beam. Cell survival increased with increasing repair time between the split dose quickly up to 60 min and saturate, as well as another cases of carbon plus x-ray or x-ray plus x-ray irradiation. We also could found the PLDR for all LET beams tested, but any LET dependency on both tumor (HSG) and normal (GM5389) cells. OER of DNA damage in CHO cells was high before repair treatment, and quickly decreased to be around 3 for x-rays. However, the repair treatment did not show any change of OER for carbon beam (80 keV/um) and the values were around 2.
重粒子線治療の最適化のための生物学研究-II.損傷修復と分割照射
