量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Radiation therapy is a cancer treatment in which a high-energy radiation is used to kill cancer cells. The production of hydroxyl radicals and other diffusible radicals is a principal cause of radiation damage to cancer. However, normal cells are affected by radiation therapy as well, and this accounts for the adverse side effects observed in this type of treatment.
Antioxidants exhibit an ability to reduce free radicals generated by radiotherapy, and thereby decrease the effectiveness of the therapy in cancer cells. If the radical scavenging activity of antioxidants is inhibited in cancer cells, they can be used in combination with radiation cancer therapy to reduce the adverse side effects. In this study, we designed a quercetin derivative, whose radical scavenging activity was decreased under acidic conditions such as caner cells. The synthesis and radical scavenging activity of the quercetin derivative will be presented.
Synthesis of Aminoquercetin for Reducing Side Effects of Cancer Radiation Therapy
