量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Systematic study on the cytotoxic and/or cytostatic effects of over twenty anticancer drugs: The crucial importance of the analytical approach and data processing
利用統計を見る
The aim of this study was to clarify the real cytotoxic effect of anticancer substances, by using a highly standardized analytical approach and precise data processing.
Over twenty anticancer drugs (new generations) were tested on cultured cell lines. Cell viability and proliferation were analysed and different data processing was applied. Based on the conventional approach for calculation of cell viability as a percentage from the respective control, all drugs could be characterized as cytotoxic. Based on the effect of the drugs on the number of viable cells in each treated sample (compared to the initial value), they could be divided in three
groups: (i) cytotoxic drugs; (ii) strongly cytostatic drugs, but not cytotoxic; (iii) drugs without effect on cell viability and with comparatively weak cytostatic effect. The study shows the crucial importance of the analytical approach and the data processing. It is obligatory to control the effect of the drug on the number of viable cancer cells during the treatment, comparing to the initial value. In most cases, the cancer cells stay alive in the presence of drug
(depending on the selecting dose) and it is a matter of time these cells to start to proliferate again after termination of the treatment.
雑誌名
Anticancer Research
巻
34
ページ
5825 - 5827
発行年
2014-10
出版者
International Institute of Anticancer Research (IIAR)
Systematic study on the cytotoxic and/or cytostatic effects of over twenty anticancer drugs: The crucial importance of the analytical approach and data processing
