量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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The present study was designed to investigate whether electroporation can facilitate the delivery of drugs inside tumors, using quantum dot (QD)-loaded polymersomes as a model. The main goal was to increase the local concentration of anticancer drugs avoiding side-effects. The experiments were performed on colon-cancer grafted mice (Balb/c) using Maestro EX Imaging System. Electroporation facilitated the delivery of nanoparticles inside the tumor. A significant difference in the fluorescence intensity between electroporated and non-electroporated mice was observed in cancer area even 24 hours after treatment with nanoparticles. The data suggest that electro-assisted delivery of size-controlled long-circulating polymersomes in cancer is a promising therapeutic strategy, especially for treatment of solid tumors.
In vivo visualization of electro-assisted delivery of nanoparticles using optical imaging
