量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Abstract
Clinical trials of carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) were conducted at the National Institute of Radiological Sciences (NIRS) in Japan between April 1995 and August 2005. In four clinical studies, we tried to determine the optimal dose and to shorten the treatment duration using five different fractionation schedules comprising 15, 12, eight, four and two fractions. There have been no treatment-related deaths and no severe adverse events. As a result of these studies, the duration of treatment could be reduced from five weeks to two days. Two-fraction therapy is currently ongoing, licensed as a Highly Advanced Medical Technology. Between April 2003 and August 2012, 133 patients with HCC underwent two fraction C-ion RT. There were no cases of grade 4 toxicity. The local control rates were 98% and 83% at one and three years, respectively, with a total dose of 45.0 GyE. Because of the low toxicity and good local control rate, C-ion RT is a promising radical and minimally invasive therapeutic option for HCC.
雑誌名
NIRS＆MedAustron Joint Symposium on Carbon Ion Radiotherapy
Carbon-ion Radiotherapy for Hepatocellular Carcinoma
