量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Abstract：
To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Between April 2001 and August 2012, 198 lesions at 189 patients were treated with C-ion RT. The dose was determined as 67.2 GyE and escalated to 70.4 GyE and 73.6 GyE. The local control rates in 197 lesions are 94 % at 3 years and 89 % at 5 years. Local control rate and survival rate at 5 years were 97 % at 73.6 GyE and 51 % at 73.6 GyE. In the literature, the reported 5-year survival rates for locally recurrent rectal cancer treated with resection were 20–40 %. Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. In this chapter, the treatment methods and the up-to-date outcomes of carbon ion radiotherapy (C-ion RT) for the recurrent rectal cancer at the NIRS are introduced.
雑誌名
NIRS＆MedAustron Joint Symposium on Carbon Ion Radiotherapy
Carbon Ion Radiotherapy for Postoperative Recurrence of Rectal Cancer
