量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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A case of an allergic reaction caused by a mouse bite occurred in our organization in 2008. Since then, we have implemented measures to prevent such incidents from occurring again.
NIRS has eleven animal facilities, where 45,000 mice, 5,000 rats and 100 monkeys are housed. A staff of 280 researchers and caretakers have contact with the laboratory animals.
The occupational health and safety monitoring of these employees requires periodical submission of a health questionnaire, and serum sampling for cryopreservation before and after working with laboratory animals. The health questionnaire asks about symptoms respondents are concerned about, and allergic symptoms, such as disorders of the eye (itchy, hyperemia), nose (watery, rhinitis), and skin (swelling, rash), as well as asthma and hives. Less than 3 % of approximately 200 of those employees per year have reported allergic symptoms over the last 9 years. A total of approximately 100 occupational health and safety accidents have occurred over the last 11 years in our institute, and 25 % of those were related to laboratory animal experiments. We have experienced incidences of anaphylaxis due to skin puncture with a syringe used on a rat in 1998, and severe allergic symptoms from a mouse bite in 2008. After the latest occurrence, we have given lectures concerning laboratory animals and allergies.
Furthermore, a routine serum antibody test against murine antigens has been introduced for employees working with murine animals as of November 2008.
Case Report: Allergy and Anaphylaxis: Measures Against Laboratory Animal Allergies in NIRS
