量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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The evaluation of drug efficacy and safety for individuals will become more reliable by performing direct dynamical study of drug itself. This is a study towards this purpose using 5-FU in animals. CSI is often used for the metabolite distribution. However, for the compounds with metabolites in wide range of chemical shift, generation of pulse covering sufficient band width is difficult for imaging instrument. One of the best methods for the dynamical study of 19F containing drug, e.g. 5-FU, has been found to be frequency selective imaging [1]. Here, we evaluate fast imaging sequences including FISP and Flash in comparison to FSE at 7T.
雑誌名
Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
19F high senseitivity imaging for in vivo drug dynamics in mice at 7T with 5-FU
