WEKO3
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We have reported\nimmunotargeting of α6β4 for radionuclide-based and near-infrared fluorescence\nimaging in a pancreatic cancer model. In this study, we prepared yttrium-90 labeled\nanti-α6β4 antibody (90Y-ITGA6B4) and evaluated its radioimmunotherapeutic efficacy\nagainst pancreatic cancer xenografts in nude mice. Mice bearing xenograft tumors\nwere randomly divided into 5 groups: (1) single administration of 90Y-ITGA6B4\n(3.7MBq), (2) double administrations of 90Y-ITGA6B4 with once-weekly schedule\n(3.7MBq x 2), (3) single administration of unlabeled ITGA6B4, (4) double\nadministrations of unlabeled ITGA6B4 with once-weekly schedule and (5) the\nuntreated control. Biweekly tumor volume measurements and immunohistochemical\nanalyses of tumors at 2 days post-administration were performed to monitor the\nresponse to treatments. To assess the toxicity, body weight was measured biweekly.\nAdditionally, at 27 days post-administration, blood samples were collected through\ncardiac puncture, and hematological parameters, hepatic and renal functions were\nanalyzed. Both 90Y-ITGA6B4 treatment groups showed reduction in tumor volumes\n(P \u003c 0.04), decreased cell proliferation marker Ki-67-positive cells and increased\nDNA damage marker p-H2AX-positive cells, compared with the other groups. Mice\ntreated with double administrations of 90Y-ITGA6B4, exhibited myelosuppression.\nThere were no significant differences in hepatic and renal functions between the 2\ntreatment groups and the other groups. Our results suggest that 90Y-ITGA6B4 is a\npromising radioimmunotherapeutic agent against α6β4 overexpressing tumors. In the\nfuture studies, dose adjustment for fractionated RIT should be considered carefully\nin order to get the optimal effect while avoiding myelotoxicity.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Inpact Journals"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "27246980", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.18632/oncotarget.9631", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "www.impactjournals.com/oncotarget/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "www.impactjournals.com/oncotarget/", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1949-2553", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "U, Winn Aung"}], "nameIdentifiers": [{"nameIdentifier": "499585", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "499586", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sudo, Hitomi"}], "nameIdentifiers": [{"nameIdentifier": "499587", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugyo, Aya"}], "nameIdentifiers": [{"nameIdentifier": "499588", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ukai, Yoshinori"}], "nameIdentifiers": [{"nameIdentifier": "499589", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kouda, Katsushi"}], "nameIdentifiers": [{"nameIdentifier": "499590", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurosawa, Yoshikazu"}], "nameIdentifiers": [{"nameIdentifier": "499591", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furukawa, Takako"}], "nameIdentifiers": [{"nameIdentifier": "499592", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saga, Tsuneo"}], "nameIdentifiers": [{"nameIdentifier": "499593", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "U Winn Aung", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "499594", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "辻 厚至", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "499595", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須藤 仁美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "499596", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須尭 綾", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "499597", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古川 高子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "499598", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐賀 恒夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "499599", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/49467", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-01-16"}, "publish_date": "2019-01-16", "publish_status": "0", "recid": "49467", "relation": {}, "relation_version_is_last": true, "title": ["Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody."], "weko_shared_id": -1}
Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody.
https://repo.qst.go.jp/records/49467
https://repo.qst.go.jp/records/49467dfe30128-913b-40ec-8a54-c7dacf3c7b1a
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-16 | |||||
タイトル | ||||||
タイトル | Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
U, Winn Aung
× U, Winn Aung× Tsuji, Atsushi× Sudo, Hitomi× Sugyo, Aya× Ukai, Yoshinori× Kouda, Katsushi× Kurosawa, Yoshikazu× Furukawa, Takako× Saga, Tsuneo× U Winn Aung× 辻 厚至× 須藤 仁美× 須尭 綾× 古川 高子× 佐賀 恒夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The contribution of integrin α6β4 (α6β4) overexpression to the pancreatic cancer invasion and metastasis has been previously shown. We have reported immunotargeting of α6β4 for radionuclide-based and near-infrared fluorescence imaging in a pancreatic cancer model. In this study, we prepared yttrium-90 labeled anti-α6β4 antibody (90Y-ITGA6B4) and evaluated its radioimmunotherapeutic efficacy against pancreatic cancer xenografts in nude mice. Mice bearing xenograft tumors were randomly divided into 5 groups: (1) single administration of 90Y-ITGA6B4 (3.7MBq), (2) double administrations of 90Y-ITGA6B4 with once-weekly schedule (3.7MBq x 2), (3) single administration of unlabeled ITGA6B4, (4) double administrations of unlabeled ITGA6B4 with once-weekly schedule and (5) the untreated control. Biweekly tumor volume measurements and immunohistochemical analyses of tumors at 2 days post-administration were performed to monitor the response to treatments. To assess the toxicity, body weight was measured biweekly. Additionally, at 27 days post-administration, blood samples were collected through cardiac puncture, and hematological parameters, hepatic and renal functions were analyzed. Both 90Y-ITGA6B4 treatment groups showed reduction in tumor volumes (P < 0.04), decreased cell proliferation marker Ki-67-positive cells and increased DNA damage marker p-H2AX-positive cells, compared with the other groups. Mice treated with double administrations of 90Y-ITGA6B4, exhibited myelosuppression. There were no significant differences in hepatic and renal functions between the 2 treatment groups and the other groups. Our results suggest that 90Y-ITGA6B4 is a promising radioimmunotherapeutic agent against α6β4 overexpressing tumors. In the future studies, dose adjustment for fractionated RIT should be considered carefully in order to get the optimal effect while avoiding myelotoxicity. |
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書誌情報 |
Oncotarget 巻 7, 号 25, p. 38835-38844, 発行日 2016-06 |
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出版者 | ||||||
出版者 | Inpact Journals | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27246980 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.9631 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | www.impactjournals.com/oncotarget/ | |||||
関連名称 | www.impactjournals.com/oncotarget/ |