doi:10.1111/cas.13727

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Permalink : http://id.nii.ac.jp/1657/00049359/

Updated long-term outcomes after carbon-ion radiotherapy for primary renal cell carcinoma. 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Kasuya Goro Tsuji Hiroshi Nomiya Takuma Makishima Hirokazu Haruyama Yasuo Kobashi Gen K Ebner Daniel Hayashi Kazuhiko Omatsu Tokuhiko Kishimoto Riwa Yasuda Shigeo Igarashi Tatsuo Oya Mototsugu Akakura Koichiro Suzuki Hiroyoshi Ichikawa Tomohiko Shimazaki Jun Kamada Tadashi Working Group for Genitourinary Tumors the
抄録	The long-term oncologic outcomes for primary renal cell carcinoma (RCC) treated with carbon-ion radiotherapy (CIRT) are poorly understood. Patients with primary RCC were treated with 12/16-fraction CIRT at our institution outside of clinical trials. The outcome data were pooled and retrospectively analyzed for toxicity, local control, and disease-free, cancer-specific, and overall survival. From 1997 to 2014, 19 RCC patients (11 with T1aN0M0, 4 with T1bN0M0, and 4 with inoperable advanced stage [T4N0M0, T3aN1M0, and T1aN0M1]) were treated with CIRT and followed up for a median of 6.6 (range, 0.7-16.5) years; 9 of these patients were inoperable because of comorbidities or advanced-stage disease. The diagnoses were confirmed by imaging in 11 patients and by biopsy in the remaining 8. In four of five patients with definitive renal comorbidities, including diabetic nephropathy, sclerotic kidney, or solitary kidney pre-CIRT progressed to grade 4 chronic kidney disease (CKD). In contrast, the remaining 14 patients without definitive renal comorbidities did not progress to grade 3 or higher CKD. Furthermore, although one case of grade 4 dermatitis was observed, there were no other grade 3 or higher non-renal adverse events. The local control rate, and disease-free, cancer-specific, and overall survival rates at 5- years of all 19 patients were 94.1%, 68.9%, 100%, and 89.2%, respectively. This updated retrospective analysis based on long-term follow-up data suggests that CIRT is a safe treatment for primary RCC patients without definitive renal comorbidities pre-CIRT, and yielding favorable treatment outcomes, even in inoperable cases. This article is protected by copyright. All rights reserved.
雑誌名	Cancer science
巻	109
号	9
ページ	2873 - 2880
発行年	2018-09
出版者	Wiley Publishing on behalf of the Japanese Cancer Association
ISSN	1347-9032
PubMed番号	29981249
DOI	10.1111/cas.13727
関連サイト	https://onlinelibrary.wiley.com/doi/full/10.1111/cas.13727
著者版フラグ	none

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