量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Abstract: Background: Type 2 diabetes mellitus (DM) has been shown to increase the risk for cognitive
decline and dementia, such as Alzheimer disease (AD) and vascular dementia (VaD). In addition to
AD and VaD, there may be a dementia subgroup associated with specific DM-related metabolic abnormalities
rather than AD pathology or cerebrovascular disease, referred to as diabetes-related dementia
(DrD).
Method: We studied 11C-PiB and 11C-PBB3 positron emission tomography (PET) in 31 subjects with
DrD and 5 subjects with AD associated with DM to assess amyloid and tau deposits in the brain.
Results: All subjects with AD showed both positive PiB and PBB3. However, only 12 out of 31 subjects
(39%) with DrD showed positive PiB, whereas 17 out of 21 subjects (81%) who underwent PBB3 PET
showed positive PBB3. Depending on the positivity of PiB and PBB3, we classified 21 subjects into a
negative PiB and a positive PBB3 pattern (11 cases, 52%), indicating tauopathy, a positive PiB and a
positive PBB3 pattern (6 cases, 29%), indicating AD pathology, or a negative PiB and a negative PBB3
pattern (4 cases, 19%). Among 11 subjects showing a negative PiB and a positive PBB3 pattern, there
were 2 PBB3 deposit patterns, including the medial temporal lobe only and extensive neocortex beyond
the medial temporal lobe.
Conclusion: DrD showed variable amyloid and tau accumulation patterns in the brain. DrD may be associated
predominantly with tau pathology, in addition to AD pathology and non-amyloid/non-tau neuronal
damage due to DM-related metabolic abnormalities.
Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia
