量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Objective: To identify the brain-volume reductions associated with frontal cognitive and behavioral impairments
in Parkinson's disease (PD).
Methods: Forty PD patients without dementia or amnesia (Hoehn and Yahr stage 3) and 10 age-matched controls
underwent brain magnetic resonance imaging. Cognitive and behavioral impairments were assessed by using the
Frontal Assessment Battery (FAB) and Frontal Systems Behavioral Scale (FrSBe), respectively. We applied voxelbased
morphometry to investigate the correlations of regional gray matter volume with FAB, FrSBe, and physical
disability.
Results: FAB was significantly lower in PD than in controls. FrSBe was significantly higher after PD onset than
before, notably in the apathy subscale. FAB and FrSBe were significantly intercorrelated. In PD patients, left
inferior frontal volume was positively correlated with FAB, whereas right precentral volume was negatively
correlated with FrSBe total score. The brain volumes in both of these regions were not correlated with the
Unified PD Rating Scale III.
Conclusion: Behavioral impairments in PD tended to coexist with progression of frontal cognitive impairment.
Regional atrophy within the frontal lobe was associated with both frontal cognitive and behavioral impairments.
However, the specific region responsible for behavioral impairment differed from that for frontal cognitive
impairment. These associations were independent of physical disability.
Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease
