量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Introduction: To facilitate radiotracers’ development, a screening methodology using a biomathematical
model and clinical usefulness index (CUI) was proposed to evaluate radiotracers’ diagnostic
capabilities.
Methods: A total of 31 amyloid positron emission tomography radiotracers were evaluated. A previously
developed biomathematical model was used to simulate 1000 standardized uptake value
ratios with population and noise simulations, which were used to determine the integrated receiver
operating characteristics curve (Az), effect size (Es), and standardized uptake value ratio (Sr) of
conditions-pairs of healthy control–mild cognitive impaired and mild cognitive impaired–
Alzheimer’s disease. CUI was obtained from the product of averaged AzðAzÞ, EsðEsÞ, and SrðSrÞ.
Results: The relationships of Az, Es, and Sr with CUI were different, suggesting that they assessed
different radiotracer properties. The combination of Az, Es, and Sr complemented each other and resulted
in CUI of 0.10 to 5.72, with clinically applied amyloid positron emission tomography radiotracers
having CUI greater than 3.0.
Discussion: The CUI rankings of clinically applied radiotracers were close to their reported clinical
results, attesting to the applicability of the screening methodology.
雑誌名
Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Biomathematical screening of amyloid radiotracers with clinical usefulness index
