量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study
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There is no reliable objective indicator for upper motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). To
determine the clinical significance and potential utility of magnetic resonance (MR) signals, we investigated the relationship
between clinical symptoms and susceptibility changes in the motor cortex measured using susceptibility-weighted MR
imaging taken by readily available 3-T MRI in clinical practice. Twenty-four ALS patients and 14 control subjects underwent
3-T MR T1-weighted imaging and susceptibility-weighted MR imaging with the principles of echo-shifting with a train of
observations (PRESTO) sequence. We analysed relationships between relative susceptibility changes in the motor cortex
assessed using voxel-based analysis (VBA) and clinical scores, including upper motor neuron score, ALS functional rating
scale revised score, and Medical Research Council sum score on physical examination. Patients with ALS exhibited significantly
lower signal intensity in the precentral gyrus on susceptibility-weighted MR imaging compared with controls. Clinical
scores were significantly correlated with susceptibility changes. Importantly, the extent of the susceptibility changes in the
bilateral precentral gyri was significantly correlated with upper motor neuron scores. The results of our pilot study using
VBA indicated that low signal intensity in motor cortex on susceptibility-weighted MR imaging may correspond to clinical
symptoms, particularly upper motor neuron dysfunction. Susceptibility-weighted MR imaging may be a useful diagnostic
tool as an objective indicator of upper motor neuron dysfunction.
Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study
