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In this large cohort of a retrospective multicenter\nstudy, we evaluated the effectiveness and safety of carbon-ion radiation therapy\nin 289 patients with adenoid cystic carcinoma of the head and neck. The physical and biological characteristics of carbon-ions allowed delivery\nof localized high tumor doses, resulting in good local control and overall survival\nwith tolerable treatmentrelated toxicity.\n\\nPurpose: To retrospectively analyze the treatment outcomes of carbon-ion radiation\ntherapy for adenoid cystic carcinoma (ACC) of the head and neck at 4 active\ncarbon-ion facilities in Japan.\nMethods and Materials: A total of 289 patients who underwent carbon-ion radiation\ntherapy for histology-proven ACC of the head and neck at 4 institutions in Japan between\nNovember 2003 and December 2014 were included in this study.\nResults: Median patient age was 58 years (range, 12-83 years). Tumor sites included\nthe nasal cavity and paranasal sinuses (42%), nasopharynx and oropharynx (19%), oral\ncavity (12%), major salivary glands (12%), and others (15%). Tumor classifications\nwere T4 in 200 (69%) patients, T3 in 45 (16%), T2 in 22 (8%), T1 in 15 (5%), and\nunclassified in 7 (2%). The median total dose was 64 Gy (relative biological effectiveness\n[RBE]; range, 55.2-70.4 Gy [RBE]) in 16 fractions (range, 12-32 fractions).\nMedian follow-up time was 30 months (range, 2-118 months). The 2-year overall survival,\nprogression-free survival, and local control rates were 94%, 68%, and 88%,\nrespectively. Estimated 5-year overall survival, progression-free survival, and local\ncontrol rates were 74%, 44%, and 68%, respectively. In all, 43 patients (15%) experienced\ngrade 3 late toxicity, of which osteonecrosis of the jaw bone was the most\ncommon. Two patients treated for nasopharyngeal ACC died from a bleeding ulcer\nat the tumor site (grade 5 toxicity).\nConclusions: Carbon-ion radiation therapy seems to be a promising treatment for\nACC of the head and neck. 2017 Elsevier Inc. 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Multicenter Study of Carbon-Ion Radiation Therapy for Adenoid Cystic Carcinoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN)
https://repo.qst.go.jp/records/48554
https://repo.qst.go.jp/records/48554c7878140-9c77-4d79-8da2-09704132d8ba
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-05 | |||||
タイトル | ||||||
タイトル | Multicenter Study of Carbon-Ion Radiation Therapy for Adenoid Cystic Carcinoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Shazrina, Sulaiman
× Shazrina, Sulaiman× Nor× Demizu, Yuusuke× Koto, Masashi× Saitou, Jyunnichi× Suefuji, Hiroaki× Tsuji, Hiroshi× Ohno, Tatsuya× Shioyama, Yoshiyuki× Okimoto, Tomoaki× Daimon, Takashi× Nemoto, Kenji× Nakano, Takashi× Kamada, Tadashi× 出水 祐介× 小藤 昌志× 齋藤 淳一× 末藤 大明× 辻 比呂志× 大野 達也× 塩山 善之× 沖本 智昭× 根本 建二× 中野 隆史× 鎌田 正 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Summary Adenoid cystic carcinomas of the head and neck are rare, comparatively radioresistant tumors. In this large cohort of a retrospective multicenter study, we evaluated the effectiveness and safety of carbon-ion radiation therapy in 289 patients with adenoid cystic carcinoma of the head and neck. The physical and biological characteristics of carbon-ions allowed delivery of localized high tumor doses, resulting in good local control and overall survival with tolerable treatmentrelated toxicity. \nPurpose: To retrospectively analyze the treatment outcomes of carbon-ion radiation therapy for adenoid cystic carcinoma (ACC) of the head and neck at 4 active carbon-ion facilities in Japan. Methods and Materials: A total of 289 patients who underwent carbon-ion radiation therapy for histology-proven ACC of the head and neck at 4 institutions in Japan between November 2003 and December 2014 were included in this study. Results: Median patient age was 58 years (range, 12-83 years). Tumor sites included the nasal cavity and paranasal sinuses (42%), nasopharynx and oropharynx (19%), oral cavity (12%), major salivary glands (12%), and others (15%). Tumor classifications were T4 in 200 (69%) patients, T3 in 45 (16%), T2 in 22 (8%), T1 in 15 (5%), and unclassified in 7 (2%). The median total dose was 64 Gy (relative biological effectiveness [RBE]; range, 55.2-70.4 Gy [RBE]) in 16 fractions (range, 12-32 fractions). Median follow-up time was 30 months (range, 2-118 months). The 2-year overall survival, progression-free survival, and local control rates were 94%, 68%, and 88%, respectively. Estimated 5-year overall survival, progression-free survival, and local control rates were 74%, 44%, and 68%, respectively. In all, 43 patients (15%) experienced grade 3 late toxicity, of which osteonecrosis of the jaw bone was the most common. Two patients treated for nasopharyngeal ACC died from a bleeding ulcer at the tumor site (grade 5 toxicity). Conclusions: Carbon-ion radiation therapy seems to be a promising treatment for ACC of the head and neck. 2017 Elsevier Inc. All rights reserved. |
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書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 100, 号 3, p. 639-646, 発行日 2018-02 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0360-3016 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijrobp.2017.11.010 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.ijrobp.2017.11.010 | |||||
関連名称 | https://doi.org/10.1016/j.ijrobp.2017.11.010 |