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Synthesis and Radical-Scavenging Activity of a Dimethylcatechin Analogue
https://repo.qst.go.jp/records/48529
https://repo.qst.go.jp/records/48529a24494e5-3450-4b40-859b-9ba15e720dd4
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-20 | |||||
タイトル | ||||||
タイトル | Synthesis and Radical-Scavenging Activity of a Dimethylcatechin Analogue | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Imai, Kohei
× Imai, Kohei× Nakanishi, Ikuo× Ohno, Akiko× Kurihara, Masaaki× Miyata, Naoki× Matsumoto, Ken-Ichiro× Nakamura, Asao× Fukuhara, Kiyoshi× 今井 耕平× 中西 郁夫× 大野 彰子× 松本 謙一郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Catechin analogue 1 with methyl substituents ortho to the catechol hydroxyl groups was synthesized to improve the antioxidant ability of (+)-catechin. The synthetic scheme involved a solid acid catalyzed Friedel-Crafts coupling of a cinnamyl alcohol derivative to 3,5-dibenzyloxyphenol followed by hydroxylation and then cyclization through an intermediate orthoester. The antioxidative radical scavenging activity of 1 against galvinoxyl radical, an oxyl radical, was found to be 28-fold more potent than (+)-catechin. | |||||
書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 24, 号 11, p. 2582-2584, 発行日 2014-03 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0960-894X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24792463 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bmcl.2014.03.029 |