WEKO3
アイテム
{"_buckets": {"deposit": "f0133991-792f-4a6f-8ba6-31c3251f2b98"}, "_deposit": {"created_by": 1, "id": "48420", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48420"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048420", "sets": ["1"]}, "author_link": ["486732", "486734", "486743", "486738", "486735", "486731", "486736", "486737", "486741", "486739", "486742", "486733", "486744", "486740"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "385", "bibliographicPageStart": "379", "bibliographicVolumeNumber": "95", "bibliographic_titles": [{"bibliographic_title": "Birth Defects Research. Part B, Developmental and Reproductive Toxicology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: Adaptive response (AR) of low linear energy transfer (LET) irradiations for protection against teratogenesis induced by high LET irradiations is not well documented. In this study, induction of AR by X-rays against teratogenesis induced by accelerated heavy ions was examined in fetal mice. METHODS: Irradiations of pregnant C57BL/6J mice were performed by delivering a priming low-dose from X-rays at 0.05 Gy or 0.30 Gy on gestation day 11 followed one day later by a challenge high-dose from either X-rays or accelerated heavy ions. Mono-energetic beams of carbon, neon, silicon and iron with the LET values of about 15, 30, 55, and 200 keV/micrometer respectively were examined. Significant suppression of teratogenic effects (fetal death, malformation of live fetuses, or low body weight) was used as the endpoint for judgment of a successful AR induction. RESULTS: Existence of AR induced by low-LET X-rays against teratogenic effect induced by high-LET accelerated heavy ions was demonstrated. The priming low-dose of X-rays significantly reduced the occurrence of prenatal fetal death, malformation and/or low body weight induced by the challenge high-dose from either X-rays or accelerated heavy ions of carbon, neon or silicon but not iron particles. CONCLUSIONS: Successful AR induction appears to be a radiation quality event, depending on the LET value and/or the particle species of the challenge irradiations. These findings would provide a new insight into the study on radiation-induced AR in utero.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/bdrb.21027", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1542-9733", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Bing, Wang"}], "nameIdentifiers": [{"nameIdentifier": "486731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ninomiya, Yasuharu"}], "nameIdentifiers": [{"nameIdentifier": "486732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "486733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Kouichi"}], "nameIdentifiers": [{"nameIdentifier": "486734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Vares, Guillaume"}], "nameIdentifiers": [{"nameIdentifier": "486735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi-Kasai, Kiyomi"}], "nameIdentifiers": [{"nameIdentifier": "486736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nenoi, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "486737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "王 冰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486738", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "二宮 康晴", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486739", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中 薫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486740", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丸山 耕一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486741", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Guillaume Vares", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486742", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笠井 清美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486743", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "根井 充", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486744", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48420", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-01-11"}, "publish_date": "2018-01-11", "publish_status": "0", "recid": "48420", "relation": {}, "relation_version_is_last": true, "title": ["Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis."], "weko_shared_id": -1}
Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis.
https://repo.qst.go.jp/records/48420
https://repo.qst.go.jp/records/48420ea51e8a1-7cbe-44f8-b26d-433e4f2d0e3b
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-01-11 | |||||
タイトル | ||||||
タイトル | Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Bing, Wang
× Bing, Wang× Ninomiya, Yasuharu× Tanaka, Kaoru× Maruyama, Kouichi× Vares, Guillaume× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× 王 冰× 二宮 康晴× 田中 薫× 丸山 耕一× Guillaume Vares× 笠井 清美× 根井 充 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Adaptive response (AR) of low linear energy transfer (LET) irradiations for protection against teratogenesis induced by high LET irradiations is not well documented. In this study, induction of AR by X-rays against teratogenesis induced by accelerated heavy ions was examined in fetal mice. METHODS: Irradiations of pregnant C57BL/6J mice were performed by delivering a priming low-dose from X-rays at 0.05 Gy or 0.30 Gy on gestation day 11 followed one day later by a challenge high-dose from either X-rays or accelerated heavy ions. Mono-energetic beams of carbon, neon, silicon and iron with the LET values of about 15, 30, 55, and 200 keV/micrometer respectively were examined. Significant suppression of teratogenic effects (fetal death, malformation of live fetuses, or low body weight) was used as the endpoint for judgment of a successful AR induction. RESULTS: Existence of AR induced by low-LET X-rays against teratogenic effect induced by high-LET accelerated heavy ions was demonstrated. The priming low-dose of X-rays significantly reduced the occurrence of prenatal fetal death, malformation and/or low body weight induced by the challenge high-dose from either X-rays or accelerated heavy ions of carbon, neon or silicon but not iron particles. CONCLUSIONS: Successful AR induction appears to be a radiation quality event, depending on the LET value and/or the particle species of the challenge irradiations. These findings would provide a new insight into the study on radiation-induced AR in utero. | |||||
書誌情報 |
Birth Defects Research. Part B, Developmental and Reproductive Toxicology 巻 95, 号 6, p. 379-385, 発行日 2012-12 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1542-9733 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/bdrb.21027 |