量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis.
利用統計を見る
BACKGROUND: Adaptive response (AR) of low linear energy transfer (LET) irradiations for protection against teratogenesis induced by high LET irradiations is not well documented. In this study, induction of AR by X-rays against teratogenesis induced by accelerated heavy ions was examined in fetal mice. METHODS: Irradiations of pregnant C57BL/6J mice were performed by delivering a priming low-dose from X-rays at 0.05 Gy or 0.30 Gy on gestation day 11 followed one day later by a challenge high-dose from either X-rays or accelerated heavy ions. Mono-energetic beams of carbon, neon, silicon and iron with the LET values of about 15, 30, 55, and 200 keV/micrometer respectively were examined. Significant suppression of teratogenic effects (fetal death, malformation of live fetuses, or low body weight) was used as the endpoint for judgment of a successful AR induction. RESULTS: Existence of AR induced by low-LET X-rays against teratogenic effect induced by high-LET accelerated heavy ions was demonstrated. The priming low-dose of X-rays significantly reduced the occurrence of prenatal fetal death, malformation and/or low body weight induced by the challenge high-dose from either X-rays or accelerated heavy ions of carbon, neon or silicon but not iron particles. CONCLUSIONS: Successful AR induction appears to be a radiation quality event, depending on the LET value and/or the particle species of the challenge irradiations. These findings would provide a new insight into the study on radiation-induced AR in utero.
雑誌名
Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis.
