量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Purpose: Head and neck (HN) adenocarcinoma is rare, and to date, there have been no
reports of prospective studies. We retrospectively evaluated the efficacy and safety of
carbon-ion radiation therapy (C-ion RT) for HN adenocarcinoma in institutions in
Japan.
Methods and Materials: HN adenocarcinoma patients with N0M0 or N1M0 disease
who were treated with C-ion RT at institutions in Japan between November 2003
and December 2014 were analyzed retrospectively. We enrolled 47 patients (30 male
and 17 female patients; median age, 60 years) with HN adenocarcinoma.
Results: Primary sites included the nasal and paranasal sinus in 21 patients, orbit in
11, salivary grand in 7, oral cavity and pharynx in 6, and acoustic organ in 2.
Thirty-two patients had T4 tumors, 6 had T3, and 6 had T2. Forty-five patients
received a diagnosis of N0 disease, whereas 2 had N1 disease. The median total dose
of C-ion RT and the number of fractions were 64.0 Gy (relative biological effectiveness)
and 16 fractions, respectively. The median follow-up period was 51 months
(range, 6-118 months). The 2- and 5-year overall survival rates were 87.9% and
60.4%, respectively, and the 2- and 5-year local control rates were 83.3% and
79.3%, respectively. Multivariate analysis showed that operability (patients with
operable tumors) (PZ.045) and fractionation (16 fractions) (PZ.010) were significant independent prognostic factors for better overall survival. No grade 5 late morbidities
were observed. Grade 4 late morbidities were observed in 4 patients, and all of
these grade 4 morbidities were visual impairments. All 4 patients with grade 4 visual
impairment had T4 tumors in the nasopharynx or paranasal sinuses, which implied
inoperable tumors with orbital or brain invasion.
A Multicenter Study of Carbon-Ion Radiation Therapy for Head and Neck Adenocarcinoma
