量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Background and purpose: The efficacy of carbon ion radiotherapy (CIRT) for bone and soft tissue sarcoma
has been reported recently. Although histological assessment after CIRT requires skilled interpretation,
little information is presently available. In this study, we report sequential histological findings after
treatment with CIRT, and evaluate the association between these findings and clinical response.
Material and methods: Seven patients with unresectable sarcoma underwent needle biopsy 12 times at an
average of 14.3 months after CIRT and were included in this study.
Results: One patient underwent two biopsies after CIRT for chordoma. Although a few suspected residual
chordoma cells were observed at 19 and 30 months after CIRT, the tumor continued to shrink at 75 months.
Immunohistochemical analysis of post-CIRT specimens revealed CK AE1/3, EMA, and S100 expression, as in
the pre-CIRT specimen. In total, viable tumor cells were found in 9 of 12 specimens; however, only 2
patients showed recurrent masses on radiological examination. The other 5 patients had stable disease.
Conclusions: Viable tumor cells after CIRT did not always cause recurrence. This may be due to observation
of dying cells or radiation-induced deformed cells. Histological evaluation after CIRT should be done
carefully.
Sequential histological findings and clinical response after carbon ion radiotherapy for unresectable sarcoma
