量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly
from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed
that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility
of Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a
sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to
investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type
(Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were
investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow
erythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per day
for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a
marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly
lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS.
CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated
erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the
incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a
significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice.
Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice
