量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Striatal and extrastriatal dopamine D2 receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [11C]raclopride and [11C]FLB457
利用統計を見る
Rationale Second-generation antipsychotics demonstrate
clinical efficacy with fewer extrapyramidal side effects compared
with first-generation antipsychotics. One of the proposed
explanations is the hypothesis of preferential
extrastriatal dopamine D2 receptor occupancy (limbic selectivity)
by antipsychotics. In the present study, we focused on
aripiprazole, which has a unique pharmacological profile with
partial agonismat dopamineD2 receptors and the minimal risk
of extrapyramidal side effects. Previous positron emission
tomography (PET) studies using high-affinity radioligands
for dopamine D2 receptors have reported inconsistent results
regarding regional differences of dopamine D2 receptor occupancy
by aripiprazole.
Striatal and extrastriatal dopamine D2 receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [11C]raclopride and [11C]FLB457
