doi:10.1017/S1461145713001521

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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
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Permalink : http://id.nii.ac.jp/1657/00047197/

Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[18F]FMeNER-D2. 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Takano Harumasa Arakawa Ryosuke Nogami Tsuyoshi Suzuki Masayuki Nagashima Tomohisa Fujiwara Hironobu Kimura Yasuyuki Kodaka Fumitoshi Takahata Keisuke Shimada Hitoshi Murakami Yoshitaka Tateno Amane Yamada Makiko Ito Hiroshi Kawamura Kazunori Zhang Ming-Rong Takahashi Hidehiko Kato Motoichiro Okubo Yoshiro Suhara Tetsuya
抄録	Norepinephrine transporter (NET) plays important roles in the treatment of various neuropsychiatric disorders, such as depression and attention deficit hyperactivity disorder (ADHD). Nortriptyline is a NET-selective tricyclic antidepressant (TCAs) that has been widely used for the treatment of depression. Previous positron emission tomography (PET) studies have reported over 80% serotonin transporter occupancy with clinical doses of selective serotonin reuptake inhibitors (SSRIs), but there has been no report of NET occupancy in patients treated with relatively NET-selective antidepressants. In the present study, we used PET and (S,S)-[18F]FMeNER-D2 to investigate NET occupancies in the thalamus in 10 patients with major depressive disorder taking various doses of nortriptyline, who were considered to be responders to the treatment. Reference data for the calculation of occupancy were derived from age-matched healthy controls. The result showed approximately 50-70% NET occupancies in the brain as a result of the administration of 75-200 mg/d of nortriptyline. The estimated effective dose (ED50) and concentration (EC50) required to induce 50% occupancy was 65.9 mg/d and 79.8 ng/ml, respectively. Furthermore, as the minimum therapeutic level of plasma nortriptyline for the treatment of depression has been reported to be 70 ng/ml, our data indicate that this plasma nortriptyline concentration corresponds to approximately 50% NET occupancy measured with PET, suggesting that more than 50% of central NET occupancy would be appropriate for the nortriptyline treatment of patients with depression.
雑誌名	The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
巻	17
号	4
ページ	553 - 560
発行年	2013-12
出版者	Cambridge, [England] : Cambridge University Press,
ISSN	1461-1457
PubMed番号	24345533
DOI	10.1017/S1461145713001521
著者版フラグ	none

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