量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice
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Age at exposure is a critical factor that influences the risk of radiation-induced leukemia, which arises from hematopoietic stem cells. However, little is known about the effect of age on the radiation response in these cells. Here we examined the radiation response of hematopoietic stem and progenitor cells in infant (1 week old), juvenile (3 weeks), and adult (8 and 14 weeks) C3H/He mice, which are susceptible to radiation induction of myeloid leukemia. We first demonstrated that infant cells were the most susceptible to radiation-induced cell killing. However, in vitro irradiation of these cells showed no age differences, suggesting that radiation sensitivity is ascribed to the bone marrow microenvironment rather than to the intrinsic nature of progenitors themselves. Expression profiles of bone marrow tissues revealed that radioprotective chemokine and cytokine expression was dependent on age at exposure and time after irradiation. There was no difference, however, in the basal expression of these factors among age groups. In contrast, radiation induction of Csf2 and Fgf1 was evident in adult tissues, but not in infant tissues. These results suggest that the decreased survival of hematopoietic stem and progenitor cells in irradiated infant mice may be attributed to a failure to induce a subset of radioprotective cytokines in the bone marrow microenvironment.
Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice
