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Evaluation of the Comet Assay for Assessing the Dose-Response Relationship of DNA Damage Induced by Ionizing Radiation.
https://repo.qst.go.jp/records/46666
https://repo.qst.go.jp/records/4666643ad2020-d57c-47d9-82d9-204f56b6e729
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-12-11 | |||||
タイトル | ||||||
タイトル | Evaluation of the Comet Assay for Assessing the Dose-Response Relationship of DNA Damage Induced by Ionizing Radiation. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yan, Wang(王 彦)
× Yan, Wang(王 彦)× Chang, Xu(徐 暢)× Li, Qing Du(杜 利清)× Jia, Cao (曹 佳)× Jian, Xiang Liu(劉 建香)× Xu, Su(蘇 旭)× Hui, Zhao(趙 輝)× Fei-Yue, Fan(樊 飛躍)× Wang, Bing× Katube, Takanori× Sai, Jun Fan(樊 賽軍)× Qiang, Liu(劉 強)× 王 冰× 勝部 孝則 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dose- and time-response curves were combined to assess the potential of the comet assay in radiation biodosimetry. The neutral comet assay was used to detect DNA double-strand breaks in lymphocytes caused by γ-ray irradiation. A clear dose-response relationship with DNA double-strand breaks using the comet assay was found at different times after irradiation (p < 0.001). A time-response relationship was also found within 72 h after irradiation (p < 0.001). The curves for DNA double-strand breaks and DNA repair in vitro of human lymphocytes presented a nice model, and a smooth, three-dimensional plane model was obtained when the two curves were combined. | |||||
書誌情報 |
International Journal of Molecular Sciences. 巻 14, 号 11, p. 22449-22461, 発行日 2013-11 |