量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Nanodevices for magnetic resonance imaging of cancer were self-assembled to coreeshell micellarstructures by metal complex formation of K2PtCl6 withdiethylenetriaminepentaacetic acid gadolinium (III) dihydrogen (Gd-DTPA), a T1-contrast agent, and poly(ethylene glycol)-b-poly{N-[N0-(2-aminoethyl)-
2-aminoethyl]aspartamide} (PEG-b-PAsp(DET)) copolymer in aqueous solution. Gd-DTPAloaded polymeric micelles (Gd-DTPA/m) showed a hydrodynamic diameter of 45 nm and a core size of 22 nm. Con!ning Gd-DTPA inside the core of the micelles increased the relaxivity of Gd-DTPA more than 13 times (48 mM!1 s!1). In physiological conditions Gd-DTPA/m sustainedly released Gd-DTPA, while the Pt(IV) complexes remain bound to the polymer. Gd-DTPA/m extended the circulation time in plasma and augmented the tumor accumulation of Gd-DTPA leading to successful contrast enhancement of solid tumors. m-Synchrotron radiation-X-ray "uorescence results con!rmed that Gd-DTPA was delivered to the tumor site by the micelles. Our study provides a facile strategy for incorporating contrast agents, dyes and bioactive molecules into nanodevices for developing safe and ef!cient drug carriers for clinical application.
Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging
