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Irradiations were \nperformed by delivering a priming low dose of X-rays (0.50 Gy) in combination with a challenge high dose \nof accelerated carbon or neon ion particles. AR was characterized by significantly decreased mortality in \nthe 30-day survival test. This mouse AR model (Yonezawa Effect) was originally established by using X-rays \nas both the priming and challenge irradiations. The underlying mechanism was due to radio-resistance oc- \ncurring in blood-forming tissues. In this study, we verified the existence of AR and further investigated re- \nsidual damage in the hematopoietic system in surviving animals. Results showed that the priming low dose \nof X-rays could relieve the detrimental effects on the hematopoietic system. We observed both an improve- \nment in the blood platelet count and the ratio of polychromatic erythrocytes (PCEs) to the sum of PCEs and \nnormochromatic erythrocytes (NCEs) and a marked reduction of the incidences of micronucleated PCEs \nand micronucleated NCEs. These findings suggest that the priming low dose of low linear energy transfer \n(LET) X-rays induced a protective effect on the hematopoietic system, which may play an important role in \nboth rescue from acute lethal damage (mouse killing) and prevention of late detrimental consequences (re- \nsidual anhematopoiesis and delayed genotoxic effects) caused by exposure to a high challenge dose from \nlow-LET (X-ray) or high-LET (carbon and neon ion) irradiations. These findings provide new knowledge \nof the characterization of the Yonezawa Effect by providing new insight into the mechanistic study of AR \nin vivo.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/jrr/rrs077", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0449-3060", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Bing, Wang"}], "nameIdentifiers": [{"nameIdentifier": "463135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "463136", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ninomiya, Yasuharu"}], "nameIdentifiers": [{"nameIdentifier": "463137", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Kouichi"}], "nameIdentifiers": [{"nameIdentifier": "463138", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Vares, Guillaume"}], "nameIdentifiers": [{"nameIdentifier": "463139", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi-Kasai, Kiyomi"}], "nameIdentifiers": [{"nameIdentifier": "463140", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nenoi, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "463141", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "王 冰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463142", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中 薫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463143", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "二宮 康晴", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463144", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丸山 耕一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463145", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Guillaume Vares", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463146", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笠井 清美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463147", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "根井 充", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463148", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect)"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46480", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-01-15"}, "publish_date": "2013-01-15", "publish_status": "0", "recid": "46480", "relation": {}, "relation_version_is_last": true, "title": ["Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect)"], "weko_shared_id": -1}
Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect)
https://repo.qst.go.jp/records/46480
https://repo.qst.go.jp/records/46480169ba5fb-8a09-4fba-bd89-d6eaea132c6c
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-01-15 | |||||
タイトル | ||||||
タイトル | Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ninomiya, Yasuharu× Maruyama, Kouichi× Vares, Guillaume× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× 王 冰× 田中 薫× 二宮 康晴× 丸山 耕一× Guillaume Vares× 笠井 清美× 根井 充 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Existence of adaptive response (AR) was previously demonstrated in C57BL/6J mice. Irradiations were performed by delivering a priming low dose of X-rays (0.50 Gy) in combination with a challenge high dose of accelerated carbon or neon ion particles. AR was characterized by significantly decreased mortality in the 30-day survival test. This mouse AR model (Yonezawa Effect) was originally established by using X-rays as both the priming and challenge irradiations. The underlying mechanism was due to radio-resistance oc- curring in blood-forming tissues. In this study, we verified the existence of AR and further investigated re- sidual damage in the hematopoietic system in surviving animals. Results showed that the priming low dose of X-rays could relieve the detrimental effects on the hematopoietic system. We observed both an improve- ment in the blood platelet count and the ratio of polychromatic erythrocytes (PCEs) to the sum of PCEs and normochromatic erythrocytes (NCEs) and a marked reduction of the incidences of micronucleated PCEs and micronucleated NCEs. These findings suggest that the priming low dose of low linear energy transfer (LET) X-rays induced a protective effect on the hematopoietic system, which may play an important role in both rescue from acute lethal damage (mouse killing) and prevention of late detrimental consequences (re- sidual anhematopoiesis and delayed genotoxic effects) caused by exposure to a high challenge dose from low-LET (X-ray) or high-LET (carbon and neon ion) irradiations. These findings provide new knowledge of the characterization of the Yonezawa Effect by providing new insight into the mechanistic study of AR in vivo. |
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書誌情報 |
Journal of Radiation Research 巻 54, 号 1, p. 45-51, 発行日 2012-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0449-3060 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jrr/rrs077 |