doi:10.1093/jrr/rrs077

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Permalink : http://id.nii.ac.jp/1657/00046467/

Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect) 利用統計は来月からご利用いただけます

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Bing Wang Tanaka Kaoru Ninomiya Yasuharu Maruyama Kouichi Vares Guillaume Eguchi-Kasai Kiyomi Nenoi Mitsuru
抄録	Existence of adaptive response (AR) was previously demonstrated in C57BL/6J mice. Irradiations were performed by delivering a priming low dose of X-rays (0.50 Gy) in combination with a challenge high dose of accelerated carbon or neon ion particles. AR was characterized by significantly decreased mortality in the 30-day survival test. This mouse AR model (Yonezawa Effect) was originally established by using X-rays as both the priming and challenge irradiations. The underlying mechanism was due to radio-resistance oc- curring in blood-forming tissues. In this study, we verified the existence of AR and further investigated re- sidual damage in the hematopoietic system in surviving animals. Results showed that the priming low dose of X-rays could relieve the detrimental effects on the hematopoietic system. We observed both an improve- ment in the blood platelet count and the ratio of polychromatic erythrocytes (PCEs) to the sum of PCEs and normochromatic erythrocytes (NCEs) and a marked reduction of the incidences of micronucleated PCEs and micronucleated NCEs. These findings suggest that the priming low dose of low linear energy transfer (LET) X-rays induced a protective effect on the hematopoietic system, which may play an important role in both rescue from acute lethal damage (mouse killing) and prevention of late detrimental consequences (re- sidual anhematopoiesis and delayed genotoxic effects) caused by exposure to a high challenge dose from low-LET (X-ray) or high-LET (carbon and neon ion) irradiations. These findings provide new knowledge of the characterization of the Yonezawa Effect by providing new insight into the mechanistic study of AR in vivo.
雑誌名	Journal of Radiation Research
巻	54
号	1
ページ	45 - 51
発行年	2012-08
ISSN	0449-3060
DOI	10.1093/jrr/rrs077
著者版フラグ	none