WEKO3
アイテム
{"_buckets": {"deposit": "73e791c2-f8d0-4082-952c-9acb5e2f9c10"}, "_deposit": {"created_by": 1, "id": "46329", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46329"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046329", "sets": ["1"]}, "author_link": ["461550", "461557", "461555", "461552", "461556", "461551", "461558", "461553", "461549", "461554"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "124", "bibliographicPageStart": "120", "bibliographicVolumeNumber": "55", "bibliographic_titles": [{"bibliographic_title": "Journal of Labelled Compounds \u0026 Radiopharmaceuticals"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We have developed an efficient synthesis method for the rapid and high-yield automated synthesis of 4-(2\u0027-methoxyphenyl)-\n1-[2\u0027-(N-2\"-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine (p-[18F]MPPF). No-carrier-added [18F]F1 was trapped on a small\nQMA cartridge and eluted with 70% MeCN(aq) (0.4 mL) containing Kryptofix 222 (2.3 mg) and K2CO3 (0.7 mg). The nucleophilic\n[18F]fluorination was performed with 3mg of the nitro-precursor in DMSO (0.4 mL) at 190 C for 20 min, followed by the\npreparative HPLC purification (column: COSMOSIL Cholester, Nacalai Tesque, Kyoto, Japan; mobile phase: MeCN/25mM\nAcONH4/AcOH = 200/300/0.15; flow rate: 6.0 mL/min) to afford p-[18F]MPPF (retention time = 9.5 min). p-[18F]MPPF was\nobtained automatically with a radiochemical yield of 38.6 5.0% (decay corrected, n = 5), a specific activity of 214.3 21.1\nGBq/mmol, and a radiochemical purity of \u003e99% within a total synthesis time of about 55 min.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/jlcr.1958", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0362-4803", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashi, Kazutaka"}], "nameIdentifiers": [{"nameIdentifier": "461549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furutsuka, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "461550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Takehito"}], "nameIdentifiers": [{"nameIdentifier": "461551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mutou, Masatoshi"}], "nameIdentifiers": [{"nameIdentifier": "461552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aki, Hatsumi"}], "nameIdentifiers": [{"nameIdentifier": "461553", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukumura, Toshimitsu"}], "nameIdentifiers": [{"nameIdentifier": "461554", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Kazutoshi"}], "nameIdentifiers": [{"nameIdentifier": "461555", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古塚 賢士", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461556", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福村 利光", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461557", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 和年", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461558", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Fully automated synthesis and purification of 4-(2\u0027-methoxyphenyl)-1-[2\u0027-(N-2\u0027\u0027-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Fully automated synthesis and purification of 4-(2\u0027-methoxyphenyl)-1-[2\u0027-(N-2\u0027\u0027-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46329", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-05-30"}, "publish_date": "2012-05-30", "publish_status": "0", "recid": "46329", "relation": {}, "relation_version_is_last": true, "title": ["Fully automated synthesis and purification of 4-(2\u0027-methoxyphenyl)-1-[2\u0027-(N-2\u0027\u0027-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine"], "weko_shared_id": -1}
Fully automated synthesis and purification of 4-(2'-methoxyphenyl)-1-[2'-(N-2''-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine
https://repo.qst.go.jp/records/46329
https://repo.qst.go.jp/records/46329b65bb6bd-c8e4-44ab-b01e-7719e5c021b4
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-05-30 | |||||
タイトル | ||||||
タイトル | Fully automated synthesis and purification of 4-(2'-methoxyphenyl)-1-[2'-(N-2''-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hayashi, Kazutaka
× Hayashi, Kazutaka× Furutsuka, Kenji× Ito, Takehito× Mutou, Masatoshi× Aki, Hatsumi× Fukumura, Toshimitsu× Suzuki, Kazutoshi× 古塚 賢士× 福村 利光× 鈴木 和年 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have developed an efficient synthesis method for the rapid and high-yield automated synthesis of 4-(2'-methoxyphenyl)- 1-[2'-(N-2"-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine (p-[18F]MPPF). No-carrier-added [18F]F1 was trapped on a small QMA cartridge and eluted with 70% MeCN(aq) (0.4 mL) containing Kryptofix 222 (2.3 mg) and K2CO3 (0.7 mg). The nucleophilic [18F]fluorination was performed with 3mg of the nitro-precursor in DMSO (0.4 mL) at 190 C for 20 min, followed by the preparative HPLC purification (column: COSMOSIL Cholester, Nacalai Tesque, Kyoto, Japan; mobile phase: MeCN/25mM AcONH4/AcOH = 200/300/0.15; flow rate: 6.0 mL/min) to afford p-[18F]MPPF (retention time = 9.5 min). p-[18F]MPPF was obtained automatically with a radiochemical yield of 38.6 5.0% (decay corrected, n = 5), a specific activity of 214.3 21.1 GBq/mmol, and a radiochemical purity of >99% within a total synthesis time of about 55 min. |
|||||
書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 55, 号 3, p. 120-124, 発行日 2012-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0362-4803 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/jlcr.1958 |