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We previously demonstrated the\nability of low doses of X-rays to induce an AR to challenging heavy-ion\nradiation (Vares et al., Mutat. Res., 2011). In this study, we assessed in\nvitro the ability of priming low doses (0.01 Gy) of heavy-ion radiation to\ninduce a similar AR to a subsequent challenging dose (1-4 Gy) of high-LET IR\n(carbon-ion: 20 and 40 keV/\u0026micro;m, neon-ion: 150 keV/\u0026micro;m) in TK6, AHH-1 and NH32\ncells. Our results showed that low doses of high-LET radiation can induce an\nAR characterized by lower mutation frequencies at Hypoxanthine-guanine\nphosphoribosyl transferase locus and faster DNA repair kinetics, in cells\nexpressing p53.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0027-5107", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Vares, Guillaume"}], "nameIdentifiers": [{"nameIdentifier": "461391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bing, Wang"}], "nameIdentifiers": [{"nameIdentifier": "461392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "461393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAKIMOTO, AYANA"}], "nameIdentifiers": [{"nameIdentifier": "461394", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi-Kasai, Kiyomi"}], "nameIdentifiers": [{"nameIdentifier": "461395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nenoi, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "461396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Guillaume Vares", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461397", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "王 冰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中 薫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柿本 彩七", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笠井 清美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461401", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "根井 充", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "461402", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46315", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-05-07"}, "publish_date": "2012-05-07", "publish_status": "0", "recid": "46315", "relation": {}, "relation_version_is_last": true, "title": ["Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation."], "weko_shared_id": -1}
Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation.
https://repo.qst.go.jp/records/46315
https://repo.qst.go.jp/records/463157a0f01e8-cbf9-44ea-a4db-4f24c0c33969
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-05-07 | |||||
タイトル | ||||||
タイトル | Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Vares, Guillaume
× Vares, Guillaume× Bing, Wang× Tanaka, Kaoru× KAKIMOTO, AYANA× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× Guillaume Vares× 王 冰× 田中 薫× 柿本 彩七× 笠井 清美× 根井 充 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adaptive response (AR) and bystander effect are two important phenomena involved in biological responses to low doses of ionizing radiation (IR). Furthermore, there is a strong interest in better understanding the biological effects of high-LET radiation. We previously demonstrated the ability of low doses of X-rays to induce an AR to challenging heavy-ion radiation (Vares et al., Mutat. Res., 2011). In this study, we assessed in vitro the ability of priming low doses (0.01 Gy) of heavy-ion radiation to induce a similar AR to a subsequent challenging dose (1-4 Gy) of high-LET IR (carbon-ion: 20 and 40 keV/µm, neon-ion: 150 keV/µm) in TK6, AHH-1 and NH32 cells. Our results showed that low doses of high-LET radiation can induce an AR characterized by lower mutation frequencies at Hypoxanthine-guanine phosphoribosyl transferase locus and faster DNA repair kinetics, in cells expressing p53. |
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書誌情報 |
Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research 巻 712, 号 1-2, p. 49-54, 発行日 2011-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-5107 |