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An efficient and expedient method for the synthesis of 11C-labeled a-aminoisobutyric acid: A tumor imaging agent potentially useful for cancer diagnosis
https://repo.qst.go.jp/records/46046
https://repo.qst.go.jp/records/4604656a1339f-8d84-4460-a2a5-46a5e2ea2959
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-05-23 | |||||
タイトル | ||||||
タイトル | An efficient and expedient method for the synthesis of 11C-labeled a-aminoisobutyric acid: A tumor imaging agent potentially useful for cancer diagnosis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kato, Koichi
× Kato, Koichi× Tsuji, Atsushi× Saga, Tsuneo× Zhang, Ming-Rong× 加藤 孝一× 辻 厚至× 佐賀 恒夫× 張 明栄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We describe the synthesis of 11C-labeled a-aminoisobutyric acid 2 from iodo[11C]methane and methyl N-(diphenylmethylen)-D,L-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted a-[11C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high and a remote-controlled synthesis was carried out. A comparative tumor positron emission tomography (PET) imaging study using the same model mouse showed higher uptake of 2 than with 11C-labeled methionine and [18F] fluorodeoxyglucose (FDG). | |||||
書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 21, 号 8, p. 2437-2440, 発行日 2011-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0960-894X |