量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Damage to intestine is a serious problem after accidental radiation. To examine substances to ameliorate damage by post-irradiation administration, we focused on the regeneration process following irradiation to intestine. Using experimental systems to examine the regeneration, effects of clinically used sex hormones were compared. An anabolic steroid, nandrolone (19-nortestosterone), stimulated proliferation in IEC-6 epithelial cells. Single injection of 19-nortestosterone ester with prolonged action to mice 24 h after abdominal irradiation at lethal dose of 15.7Gy showed significant life-saving effect. Regeneration indicators as microcolonies of BrdU-incorporated cells at Day 5 and c-myb mRNA expression levels at Day 4 were enhanced by 19-nortestosterone administration. In contrast, high concentration of estradiol inhibited growth of IEC-6. Introduction of estradiol ester to abdominally irradiated mice decreased levels of regeneration indicators and survival rate. These results suggest the effectiveness of anabolic steroid as well as the importance of manipulation of steroid receptors in the recovery of mucosa damaged by radiation.
Acceleration of Regeneration of Mucosa in Small Intestine Damaged by Ionizing Radiation using Anabolic Steroids.
