doi:10.1186/1471-2407-10-381

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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
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Permalink : http://id.nii.ac.jp/1657/00045998/

An open cohort study of bone metastasis incidence following surgery in breast cancer patients 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Koizumi Mitsuru Yoshimoto Masataka Kasumi Fujio Iwase Takuji
抄録	Background: To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. Methods: Consecutive breast cancer patients undergoing surgery between 1988 and 1998 (5459 patients) were followed up regarding bone metastasis until December 2006. Patients characteristics at the time of surgery were analyzed by Cox method, with bone metastasis as events. Patient groups were assigned according to Cox analysis, and were judged either to require the adjuvant bisphosphonate or not, using the tentative criteria: high risk (>3% person-year), medium risk (1-3%), and low risk (<1%). Results: Bone metastasis incidence was constant between 1.0 and 2.8% per person-year more than 10 years. Noninvasive cancer was associated with a very low incidence of bone metastasis (1/436). Multivariate Cox analysis indicated important factors for bone metastasis were tumor grade (T), nodal grade (pN), and histology. Because T and pN were important factors for bone metastasis prediction, subgroups were made by pTNM stage. Patients at stages IIIA, IIIB and IV had an incidence of >3% per person-year, patients with stage I <1% per person-year, and those with stages II were between 1 and 3%. Further analysis with histology in stage II patients showed that stage IIB with high risk histology also had a high incidence (3% person year), whereas stage IIA with medium risk histology were <1%. Conclusions: Bone metastasis incidence remained constant for many years. Using pN, T, and histopathology, patients could be classified into high, medium, and low risk groups.
雑誌名	BMC Cancer (Online only:URL:http://www.biomedcentral.com/bmccancer)
巻	10
号	381
ページ	1 - 8
発行年	2010-07
ISSN	1471-2407
DOI	10.1186/1471-2407-10-381
関連サイト	http://www.biomedcentral.com/1471-2407/10/381
著者版フラグ	none

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