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Visualization of early infarction in rat brain after ischemia using a translocator protein (18 kDa) PET ligand [11C]DAC with ultra-high specific activity
https://repo.qst.go.jp/records/45970
https://repo.qst.go.jp/records/4597098863013-b303-4ef7-8dfa-b5f00e2b29d3
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-12-20 | |||||
タイトル | ||||||
タイトル | Visualization of early infarction in rat brain after ischemia using a translocator protein (18 kDa) PET ligand [11C]DAC with ultra-high specific activity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yui, Joji
× Yui, Joji× Hatori, Akiko× Kawamura, Kazunori× Yamasaki, Tomoteru× Yanamoto, Kazuhiko× Yoshida, Yuichiro× Ogawa, Masanao× Kumata, Katsushi× Fujinaga, Masayuki× Nengaki, Nobuki× Fukumura, Toshimitsu× Suzuki, Kazutoshi× Zhang, Ming-Rong× 由井 譲二× 羽鳥 晶子× 河村 和紀× 山崎 友照× 柳本 和彦× 吉田 勇一郎× 小川 政直× 熊田 勝志× 藤永 雅之× 念垣 信樹× 福村 利光× 鈴木 和年× 張 明栄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to visualize early infarction in the rat brain after ischemia using a translocator protein (TSPO) (18 kDa) PET ligand [11C]DAC with ultra-high specific activity (SA) of 3670–4450 GBq/mumol. An infarction model of rat brain was prepared by ischemic surgery and evaluated 2 days after ischemia using small-animal PET and in vitro autoradiography. Early infarction with a small increase of TSPO expression in the brain was visualized using PET with high SA [11C]DAC (average 4060 GBq/mumol), but was not distinguished clearly with usually reported SA [11C]DAC (37 GBq/mumol). Infarction in the rat brain 4 days after ischemia was visualized using high and usually reported SAs [11C]DAC. Displacement experiments with unlabeled TSPO-selective AC-5216 or PK11195 diminished the difference in radioactivity between ipsilateral and contralateral sides, confirming that the increased uptake on the infracted brain was specific to TSPO. In vitro autoradiography with high SA [11C]DAC showed that the TSPO expression increased on early infarction in the rat brain. High SA [11C]DAC is a useful and sensitive biomarker for the visualization of early infarction and the characterization of TSPO expression which was slightly elevated in the infarcted brain using PET. |
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書誌情報 |
NeuroImage 巻 54, 号 1, p. 123-130, 発行日 2011-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1053-8119 |