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METHODS AND MATERIALS: Between April 2000 and November 2003, a Phase II study of 175 prostate cancer patients was performed to assess C-ion RT with a dose fractionation (66 Gray equivalent in 20 fractions) established from previous Phase I-II studies. The effects of the clinical and dosimetric parameters on the occurrence of persistent GU toxicity in 172 patients who survived for \u003e18 months after C-ion RT were examined retrospectively. C-ion RT alone was performed for 33 low-risk patients, and 139 high-risk patients received C-ion RT combined with androgen deprivation therapy (ADT). RESULTS: Grade 1 and 2 persistent GU toxicities developed in 36 (21%) and 3 (2%) patients, respectively. The use of long-course ADT (\u003eor=24 months) and acute GU toxicity were associated with the occurrence of persistent toxicity by multivariate analysis (p = 0.016 and p = 0.048, respectively), but short-course ADT (\u003c24 months) had no effect on the development of toxicity (p = 0.35). The 5-year actuarial complication rate of 80 patients undergoing long-course ADT was 31.1%; the corresponding rate for the 92 patients who received no ADT or short-course ADT was 22.2%. CONCLUSION: Adverse effects with long-course ADT on persistent GU morbidity were observed in this study. Additional investigation is needed to identify suitable ADT administration according to risk groups, but long-course ADT should not be adopted for non-high-risk prostate cancer patients to reduce the GU toxicity rate with C-ion RT.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0360-3016", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ishikawa, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "455804", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "455805", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamada, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "455806", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirasawa, Naoki"}], "nameIdentifiers": [{"nameIdentifier": "455807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagi, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "455808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizoe, Junetsu"}], "nameIdentifiers": [{"nameIdentifier": "455809", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akakura, Kouichirou"}], "nameIdentifiers": [{"nameIdentifier": "455810", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimazaki, Jun"}], "nameIdentifiers": [{"nameIdentifier": "455811", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "455812", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujii, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "455813", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "455814", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "石川 仁", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455815", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "辻 比呂志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455816", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田 正", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455817", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平澤 直樹", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柳 剛", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455819", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "溝江 純悦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "赤倉 功一郎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島崎 淳", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中野 隆史", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "辻井 博彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "455824", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/45835", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-06-28"}, "publish_date": "2010-06-28", "publish_status": "0", "recid": "45835", "relation": {}, "relation_version_is_last": true, "title": ["Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer"], "weko_shared_id": -1}
Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer
https://repo.qst.go.jp/records/45835
https://repo.qst.go.jp/records/4583589f653fd-39e7-4d5f-bc79-8d090c9ea3d1
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-06-28 | |||||
タイトル | ||||||
タイトル | Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ishikawa, Hitoshi
× Ishikawa, Hitoshi× Tsuji, Hiroshi× Kamada, Tadashi× Hirasawa, Naoki× Yanagi, Takeshi× Mizoe, Junetsu× Akakura, Kouichirou× Shimazaki, Jun× Nakano, Takashi× Tsujii, Hirohiko× et.al× 石川 仁× 辻 比呂志× 鎌田 正× 平澤 直樹× 柳 剛× 溝江 純悦× 赤倉 功一郎× 島崎 淳× 中野 隆史× 辻井 博彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: To determine the risk factors for persistent late genitourinary (GU) morbidity after carbon ion radiotherapy (C-ion RT) for prostate cancer. METHODS AND MATERIALS: Between April 2000 and November 2003, a Phase II study of 175 prostate cancer patients was performed to assess C-ion RT with a dose fractionation (66 Gray equivalent in 20 fractions) established from previous Phase I-II studies. The effects of the clinical and dosimetric parameters on the occurrence of persistent GU toxicity in 172 patients who survived for >18 months after C-ion RT were examined retrospectively. C-ion RT alone was performed for 33 low-risk patients, and 139 high-risk patients received C-ion RT combined with androgen deprivation therapy (ADT). RESULTS: Grade 1 and 2 persistent GU toxicities developed in 36 (21%) and 3 (2%) patients, respectively. The use of long-course ADT (>or=24 months) and acute GU toxicity were associated with the occurrence of persistent toxicity by multivariate analysis (p = 0.016 and p = 0.048, respectively), but short-course ADT (<24 months) had no effect on the development of toxicity (p = 0.35). The 5-year actuarial complication rate of 80 patients undergoing long-course ADT was 31.1%; the corresponding rate for the 92 patients who received no ADT or short-course ADT was 22.2%. CONCLUSION: Adverse effects with long-course ADT on persistent GU morbidity were observed in this study. Additional investigation is needed to identify suitable ADT administration according to risk groups, but long-course ADT should not be adopted for non-high-risk prostate cancer patients to reduce the GU toxicity rate with C-ion RT. | |||||
書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 72, 号 1, p. 78-84, 発行日 2008-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0360-3016 |