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METHODS: Two PET scanning with [(11)C]verapamil were performed before and after administration of 400 mg/day of clarithromycin on each of four healthy male subjects. The rate constant of transfer from plasma to brain (K (1)) was estimated by integration plot method. RESULTS: K (1) values of [(11)C]verapamil before administration of clarithromycin were 0.042-0.070 mL/cm(3)/min (0.054 +/- 0.012) and those after administration were 0.037-0.066 mL/cm(3)/min (0.055 +/- 0.013). No significant change in K (1) values of [(11)C]verapamil was observed between before and after administration of clarithromycin (P = 0.85). CONCLUSION: K (1) values of [(11)C]verapamil were not changed by clinical dose administration of clarithromycin, suggesting that a clinical dose of clarithromycin does not affect P-gp function at the blood-brain barrier.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0914-7187", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Arakawa, Ryosuke"}], "nameIdentifiers": [{"nameIdentifier": "454983", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "454984", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "454985", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morimoto, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "454986", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie"}], "nameIdentifiers": [{"nameIdentifier": "454987", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Hidehiko"}], "nameIdentifiers": [{"nameIdentifier": "454988", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takano, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "454989", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "454990", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "荒川 亮介", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454991", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤 浩", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454992", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "奥村 正紀", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454993", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森本 卓哉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454994", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "関 千江", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454995", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋 英彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454996", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高野 晶寛", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454997", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "454998", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/45769", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-03-19"}, "publish_date": "2010-03-19", "publish_status": "0", "recid": "45769", "relation": {}, "relation_version_is_last": true, "title": ["No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil"], "weko_shared_id": -1}
No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil
https://repo.qst.go.jp/records/45769
https://repo.qst.go.jp/records/45769c540bbd5-e13a-4ca3-882d-cb18158d7fde
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-19 | |||||
タイトル | ||||||
タイトル | No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Arakawa, Ryosuke
× Arakawa, Ryosuke× Ito, Hiroshi× Okumura, Masaki× Morimoto, Takuya× Seki, Chie× Takahashi, Hidehiko× Takano, Akihiro× Suhara, Tetsuya× 荒川 亮介× 伊藤 浩× 奥村 正紀× 森本 卓哉× 関 千江× 高橋 英彦× 高野 晶寛× 須原 哲也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To investigate the effects of the clinical dose of clarithromycin, a substrate of P-glycoprotein (P-gp), on P-gp function using positron emission tomography (PET) with [(11)C]verapamil. METHODS: Two PET scanning with [(11)C]verapamil were performed before and after administration of 400 mg/day of clarithromycin on each of four healthy male subjects. The rate constant of transfer from plasma to brain (K (1)) was estimated by integration plot method. RESULTS: K (1) values of [(11)C]verapamil before administration of clarithromycin were 0.042-0.070 mL/cm(3)/min (0.054 +/- 0.012) and those after administration were 0.037-0.066 mL/cm(3)/min (0.055 +/- 0.013). No significant change in K (1) values of [(11)C]verapamil was observed between before and after administration of clarithromycin (P = 0.85). CONCLUSION: K (1) values of [(11)C]verapamil were not changed by clinical dose administration of clarithromycin, suggesting that a clinical dose of clarithromycin does not affect P-gp function at the blood-brain barrier. | |||||
書誌情報 |
Annals of Nuclear Medicine 巻 24, 号 2, p. 83-87, 発行日 2010-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0914-7187 |