doi:10.1016/j.radonc.2007.05.012

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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
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Permalink : http://id.nii.ac.jp/1657/00045651/

A Regional Cooperative Clinical Study of Radiotherapy for Cervical Cancer in East and South-East Asian Countries 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Nakano Takashi Kato Shingo Cao JianPing Juying Zhou Raden Susworo Nana Supriana Satou Shinichirou Ohno Tatsuya Suto Hisao Nakamura Yuzuru Koo Chul Cho Fuad Ismail Joy C Calaguas Miriam H De Los Reyes Rey Chansilpa Yaowalak Thephamongkhol Kullathorn Nguyen Ba Duc To Anh Dung Tsujii Hirohiko
抄録	Purpose \nRadiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. \nMaterials and methods \nEleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT. \nResults \nHundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. \nConclusions \nAlthough there were several problems with treatment compliance and patients follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia. \nKeywords: Cervical cancer; Radiotherapy; Developing country; International clinical study; East and south-east Asia
雑誌名	Radiotherapy and Oncology
巻	84
号	3
ページ	314 - 319
発行年	2007-05
ISSN	0167-8140
DOI	10.1016/j.radonc.2007.05.012
著者版フラグ	none

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