量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Prenatal irradiations with accelerated-heavy-ion beams induced LET-dependent detrimental effects on prenatal development and postnatal neurophysiologic accomplishment in rats.
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In a series of investigation, effects from high-LET prenatal irradiation on prenatal and postnatal development were studied in offspring following exposure of pregnant Wistar rats to accelerated-heavy-ion beams on the 15th day of gestation. The dose delivered to the pregnant dams varied with the ion particles ranging from 0.1 to 2.5Gy. The outcome of birth and the body weight were recorded. The age at which four physiologic markers appeared and five reflexes acquired was examined prior to weaning. Gain in body weight of the offspring was monitored and two behavioral tests were evaluated in the male offspring. The effects of X-rays at 200 kVp measured for the same biological end points were studied for comparison. The AD50, the mean age for 50% of the offspring in each group qualify for the end point, was used for further analysis of developmental end points. Based on the AD50 data and the results that we published previously, the RBE values and relative attitude of biological effect from accelerated-heavy-ion beams were calculated and presented in this study. These results indicated that the detrimental effects were dependent on both dose and LET of the irradiations.
Prenatal irradiations with accelerated-heavy-ion beams induced LET-dependent detrimental effects on prenatal development and postnatal neurophysiologic accomplishment in rats.
