量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Background:A phase I/II study was first conducted for the treatment of stage I non-small cell lung cancer(NSCLC)from 1994 to 1999 to determine the optimal dose.On the basis on the results,a phase II study using a regimen of four fractions during 1 week was performed.The purpose of the present study was to determine the local control and 5-year survival rates.
Methods:From December 2000 to November 2003,79 patients with 80 primary lesions were treated. Using a fixed dose of 52.8 GyE for stage IA NSCLC and 60.0 GyE for stage IB NSCLC in four fractions during 1 week,the primary tumors were irradiated with carbon beams alone.The average age of the patients was 74.8 years.Sixty-two(78.5%)of these patients were medically inoperable.Local control and survival were determined using the Kaplan-Meier method.The data were statistically processed using the log-rank test.
Results:All patients were observed for a minimum of 3 years or until death,with a median follow-up time of 38.6 months,ranging from 2.5 to 72.2 months.The local control rate for all patients was 90%(T1:98%,T2:80%).The patients'5-year lung cancer-specific survival rate was 68%(IA:87%,IB:42%).The overall survival was 45%(IA:62%,IB:25%).Harf of the deaths were attributable to intercurrent diseases.No toxic reactions in the lung greater than grade 3 were detected.
Conclusion:Carbon ion beam radiotherapy with a regimen of four fractions during 1 week has been proven as a valid alternative to surgery for stage INCLC and to offer particular benefits,especially for elderly and inoperable patients.
Carbon Ion Radiotherapy for Stage I Non-small Cell Lung Cancer Using a Regimen of Four Fractions during 1 Week
