WEKO3
アイテム
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Enhanced dopamine release by nicotine in cigarette smokers:a duuble-blind,randomized,placebo-controlled pilot study
https://repo.qst.go.jp/records/45148
https://repo.qst.go.jp/records/451488ad12a9f-b1df-43bb-9efa-eb571d9b91d6
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-05-07 | |||||
タイトル | ||||||
タイトル | Enhanced dopamine release by nicotine in cigarette smokers:a duuble-blind,randomized,placebo-controlled pilot study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takahashi, Hidehiko
× Takahashi, Hidehiko× Fujimura, Yota× Hayashi, Mika× Takano, Harumasa× Okubo, Yoshiro× Kanno, Iwao× Ito, Hiroshi× Suhara, Tetsuya× et.al× 高橋 英彦× 藤村 洋太× 林 海香× 高野 晴成× 大久保 善朗× 菅野 巖× 伊藤 浩× 須原 哲也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Previous studies of smoking on dopamine release in humans were investigated only in smokers. Using nicotine gum, we examined the effect of nicotine on dopamine release in smokers and non-smokers and its relation to the degree of nicotine dependence. Smokers and non-smokers participated in a double-blind, randomized, placebo-controlled cross-over study. They participated in two PET measurements with [11C]raclopride, in which they received either nicotine or placebo. Changes in [11C]raclopride non-displaceable binding potential (BPND) following nicotine administration were quantified. Smokers showed significant decrease in BP in the striatum following nicotine administration, but non-smokers did not show such a decrease. The BPND difference between the two scanning sessions was correlated with the degree of nicotine dependence. The BPND difference might reflect enhanced dopamine release in smokers and the reinforced effect of nicotine. These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system. | |||||
書誌情報 |
The International Journal of Neuropsychopharmacology 巻 11, 号 3, p. 413-417, 発行日 2008-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1461-1457 |