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RNA interference - about the reality to be exploited in cancer therapy
https://repo.qst.go.jp/records/45126
https://repo.qst.go.jp/records/4512613e244f0-a529-4789-a5ec-a1f58cbf86b6
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-25 | |||||
タイトル | ||||||
タイトル | RNA interference - about the reality to be exploited in cancer therapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Bakalova-Zheleva, Rumiana
× Bakalova-Zheleva, Rumiana× バカロバ ルミアナ |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The discovery of RNA interference (RNAi) in mammalian cells raises the expectations of gene therapy, especially in cancer. However, it is too early to say how great this promise may be because of many disputable problems including intracellular delivery of siRNA, the transient nature of RNAi and potential side effects after long-term treatment. The present microarray study demonstrates that the RNAi of one oncogene (encoding bcr-abl fusion protein in chronic myelogenous leukemia) triggers an overexpression of other "sleeping" oncogenes, antiapoptotic genes and factors, preserving the immortalization of bcr-abl-positive leukemia cells. | |||||
書誌情報 |
Methods and Findings in Experimental and Clinical Pharmacology 巻 29, 号 6, p. 417-421, 発行日 2007 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0379-0355 |