WEKO3
アイテム
{"_buckets": {"deposit": "d4a4cddc-eeee-44b7-99d5-5118c945c60c"}, "_deposit": {"created_by": 1, "id": "44855", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "44855"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00044855", "sets": ["1"]}, "author_link": ["445453", "445455", "445451", "445457", "445454", "445452", "445450", "445456"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "344", "bibliographicPageStart": "334", "bibliographicVolumeNumber": "24", "bibliographic_titles": [{"bibliographic_title": "Neurobiology of Disease"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The M5 muscarinic acetylcholine receptor (M5R) has been shown to play a crucial role in mediating acetylcholine-dependent dilation of cerebral blood vessels. We show that male M5R-/- mice displayed constitutive constriction of cerebral arteries using magnetic resonance angiography in vivo. Male M5R-/- mice exhibited a significantly reduced cerebral blood flow (CBF) in the cerebral cortex, hippocampus, basal ganglia, and thalamus. Cortical and hippocampal pyramidal neurons from M5R-/- mice showed neuronal atrophy. Hippocampus-dependent spatial and nonspatial memory was also impaired in M5R-/- mice. In M5R-/- mice, CA3 pyramidal cells displayed a significantly attenuated frequency of the spontaneous postsynaptic current and long-term potentiation was significantly impaired at the mossy fiber-CA3 synapse. Our findings suggest that impaired M5R signaling may play a role in the pathophysiology of cerebrovascular deficits. The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0969-9961", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Araya, Runa"}], "nameIdentifiers": [{"nameIdentifier": "445450", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noguchi, Takanori"}], "nameIdentifiers": [{"nameIdentifier": "445451", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuhki, Munehiro"}], "nameIdentifiers": [{"nameIdentifier": "445452", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "445453", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanno, Iwao"}], "nameIdentifiers": [{"nameIdentifier": "445454", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "445455", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口 真人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "445456", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菅野 巖", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "445457", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/44855", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-28"}, "publish_date": "2007-05-28", "publish_status": "0", "recid": "44855", "relation": {}, "relation_version_is_last": true, "title": ["Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice."], "weko_shared_id": -1}
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.
https://repo.qst.go.jp/records/44855
https://repo.qst.go.jp/records/448557bdb007c-4842-49b6-a46e-1aa42657af56
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-05-28 | |||||
タイトル | ||||||
タイトル | Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Araya, Runa
× Araya, Runa× Noguchi, Takanori× Yuhki, Munehiro× Higuchi, Makoto× Kanno, Iwao× et.al× 樋口 真人× 菅野 巖 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The M5 muscarinic acetylcholine receptor (M5R) has been shown to play a crucial role in mediating acetylcholine-dependent dilation of cerebral blood vessels. We show that male M5R-/- mice displayed constitutive constriction of cerebral arteries using magnetic resonance angiography in vivo. Male M5R-/- mice exhibited a significantly reduced cerebral blood flow (CBF) in the cerebral cortex, hippocampus, basal ganglia, and thalamus. Cortical and hippocampal pyramidal neurons from M5R-/- mice showed neuronal atrophy. Hippocampus-dependent spatial and nonspatial memory was also impaired in M5R-/- mice. In M5R-/- mice, CA3 pyramidal cells displayed a significantly attenuated frequency of the spontaneous postsynaptic current and long-term potentiation was significantly impaired at the mossy fiber-CA3 synapse. Our findings suggest that impaired M5R signaling may play a role in the pathophysiology of cerebrovascular deficits. The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function. | |||||
書誌情報 |
Neurobiology of Disease 巻 24, 号 2, p. 334-344, 発行日 2006-11 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-9961 |