　【重要】サーバ移転のお知らせ
　　いつも当サイトをご利用いただき誠にありがとうございます。当サイトは2019/03/11にJAIROCloudへサーバ移転致しました。
　サーバ移転の関係上、2019/03/10以前にブックマークされたURL（URI）にアクセスしますと、「アイテムが削除されています」のアラートBOXが表示されます。
　ご利用の皆様には大変お手数をおかけしますが、当サイトより改めて必要なページを検索し再度ブックマークして頂きますようお願い申し上げます。

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　量子科学技術研究開発機構　学術機関リポジトリ担当

　　Thank you very much for using our website. On the 11th of March 2019, this site was moved from our own network server to the JAIRO Cloud network server.
　　If you previously bookmarked this site, that bookmark will no longer work.
　　We would be grateful if you could bookmark the website again. Thank you very much for your understanding and cooperation.

　　　　>>about

量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
　　　　close<<

お知らせ

2019.03.11 JAIROCloudへサーバ移転し、サイトをリニューアルしました。

WEKO


	トップ


	ランキング

Language

インデックスツリー

インデックス

原著論文

Permalink : http://id.nii.ac.jp/1657/00044548/

Protective Effects of Melatonin Against Low- and High-LET Irradiation 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Zhou Guangming Kawata Tetsuya Furusawa Yoshiya Aoki Mizuho Hirayama Ryoichi Ando Koichi Ito Hisao
抄録	To investigate the protective effects of melatonin against high-LET ionizing radiation, V79 Chinese hamster cells were irradiated with 100 keV/um carbon beam. Parallel experiments were performed with 200 kV X-rays. To avoid the impact from extra solvents, melatonin was dissolved directly in culture medium. Cells were cultured in melatonin medium for 1 hr before irradiation. Cell inactivation was measured with conventional colony forming assay, medium containing 6-thioguanine was used for the selection of mutants at hprt locus, and the cell cycle was monitored by flow cytometry. Both carbon beam and X-rays induced cell inactivation, hprt gene mutation and cell cycle G2 block dose-dependently. But carbon beam showed stronger effects as indicated by all three endpoints and the relative biological effectiveness (RBE) was 3.5 for cell killing (at 10% survival level) and 2.9 for mutation induction (at 5x10^-5 mutants/cell level). Melatonin showed protective effects against ionizing radiation in a dose-dependent manner. In terms of cell killing, melatonin only increased the survival level of those samples exposed to 8Gy or larger of X-rays or 6 Gy or larger of carbon beam. In the induction of hprt mutation and G2 block, melatonin reduced such effects induced by carbon beam but not by X-rays. The results suggest that melatonin reduces the direct interaction of particles with cells rather than an indirect interaction. Further studies are required to disclose the underlying mechanisms.
雑誌名	Journal of Radiation Research
巻	47
号	2
ページ	175 - 181
発行年	2006-06
ISSN	0449-3060
著者版フラグ	none

訪問者数

更新情報 Recent info

リンク　Link

検索