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Design and Evaluation of Radioactive Acetylcholine Analogs for Mapping Brain Acetylcholinesterase (AchE) In Vivo
https://repo.qst.go.jp/records/44447
https://repo.qst.go.jp/records/4444737ee2676-3ff3-44fb-bd69-536b5d642218
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2006-07-07 | |||||
タイトル | ||||||
タイトル | Design and Evaluation of Radioactive Acetylcholine Analogs for Mapping Brain Acetylcholinesterase (AchE) In Vivo | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Irie, Toshiaki
× Irie, Toshiaki× Fukushi, Kiyoshi× et.al× 入江 俊章× 福士 清 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For mapping brain acetylcholinesterase (AchE) in vivo. seven radioactive acetylcholine analogs, N-[14C]methylpiperidyl-3- and 4-acetates, propionates, isobutyrates, and 3-butyrate were newly synthesized and evaluated in mice. The esters readily entered the brain and were hydrolyzed into the hydrophilic metabolite, which was trapped. In brain homogenates, the esters showed a wide range of enzymatic reactivity (about 40-fold), and high specificity for AchE (more than 82%) except the butrate. Intra-brain distribution of the esters reflected a pattern of AchE activity. | |||||
書誌情報 |
Nuclear Medicine and Biology 巻 21, 号 6, p. 801-808, 発行日 1994 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-8051 |