WEKO3
アイテム
{"_buckets": {"deposit": "16e5d351-24d9-4c6d-a389-4a743bf117c4"}, "_deposit": {"created_by": 1, "id": "44322", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "44322"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00044322", "sets": ["1"]}, "author_link": ["440267", "440270", "440262", "440266", "440269", "440263", "440264", "440265", "440268", "440257", "440260", "440258", "440259", "440261", "440271", "440272"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "133", "bibliographicPageStart": "131", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Synapse"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In previous studies, we have found that [11C]L-703,717,a positron-emitter labeled antagonist for the glycine-binding site of NMDA receptors,only localizes in rodent cerebellum under in vivo conditions. In order to understand the unusual cerebellar localization,we have examined the binding of [11C]L-703,717 to a cerebellar specific NMDA receptor subtype consisting of GLuRepsilon3 subunit,by comparing its auto-radiographic distributions between GluRepsilon3-deficient and wild-type mice. Ex vivo [11C]L-703,717 binding to wild-type mice showed a highly specific localization of radioactivity in the cerebellum,whereas that to the GluRepsilon3-deficient mice showed no specific localization of radioactivity in any of the brain regions. In contrast to the ex vivo binding,in vitro[11C]L-703,717 binding displayed a similar binding characteristic between GluRepsilon3-deficient and wild-type mice with highly specific localizations in the hippocampus and cerebral cortex. Therefore,the present study clearly demonstrated that [11C]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRepsilon3 subunit in vivo,but not in vitro. Synapse 43:131-133,2002.\n(C)2001 Wiley-Liss,Inc.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0887-4476", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Haradahira, Terushi"}], "nameIdentifiers": [{"nameIdentifier": "440257", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okauchi, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "440258", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Jun"}], "nameIdentifiers": [{"nameIdentifier": "440259", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "440260", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kida, Takayo"}], "nameIdentifiers": [{"nameIdentifier": "440261", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawabe, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "440262", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mishina, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "440263", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Yasuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "440264", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Kazutoshi"}], "nameIdentifiers": [{"nameIdentifier": "440265", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "440266", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "原田平 輝志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "440267", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡内 隆", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "440268", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "前田 純", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "440269", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "440270", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 和年", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "440271", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "440272", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/44322", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-06-23"}, "publish_date": "2006-06-23", "publish_status": "0", "recid": "44322", "relation": {}, "relation_version_is_last": true, "title": ["A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro"], "weko_shared_id": -1}
A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro
https://repo.qst.go.jp/records/44322
https://repo.qst.go.jp/records/44322aec40050-39a6-4109-8df0-f5ba0360a890
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2006-06-23 | |||||
タイトル | ||||||
タイトル | A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Haradahira, Terushi
× Haradahira, Terushi× Okauchi, Takashi× Maeda, Jun× Zhang, Ming-Rong× Kida, Takayo× Kawabe, Koichi× Mishina, Masahiro× Watanabe, Yasuyoshi× Suzuki, Kazutoshi× Suhara, Tetsuya× 原田平 輝志× 岡内 隆× 前田 純× 張 明栄× 鈴木 和年× 須原 哲也 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In previous studies, we have found that [11C]L-703,717,a positron-emitter labeled antagonist for the glycine-binding site of NMDA receptors,only localizes in rodent cerebellum under in vivo conditions. In order to understand the unusual cerebellar localization,we have examined the binding of [11C]L-703,717 to a cerebellar specific NMDA receptor subtype consisting of GLuRepsilon3 subunit,by comparing its auto-radiographic distributions between GluRepsilon3-deficient and wild-type mice. Ex vivo [11C]L-703,717 binding to wild-type mice showed a highly specific localization of radioactivity in the cerebellum,whereas that to the GluRepsilon3-deficient mice showed no specific localization of radioactivity in any of the brain regions. In contrast to the ex vivo binding,in vitro[11C]L-703,717 binding displayed a similar binding characteristic between GluRepsilon3-deficient and wild-type mice with highly specific localizations in the hippocampus and cerebral cortex. Therefore,the present study clearly demonstrated that [11C]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRepsilon3 subunit in vivo,but not in vitro. Synapse 43:131-133,2002. (C)2001 Wiley-Liss,Inc. |
|||||
書誌情報 |
Synapse 巻 43, p. 131-133, 発行日 2002 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0887-4476 |