量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Exposure to radiation during brain development stage cause microcephaly or mental retardation. Although X- and gamma-rays induced cerebral hypoplasia in rodents has been well characterized, little is known about such effects of neutrons. To examine the effects of prenatal exposure to neutrons on the brain and other organs development, B6C3F1 mice both sexes were irradiated with fast neutrons (0.1, 0.2, 0.5, 1Gy) or gamma-rays (0.8, 1.5Gy) at embryonic day 13.5, and the animals were examined histopathologically 56 days after birth. Both types of radiation mainly caused hypoplasia of the cerebral cortex and lowered brain absolute weight. No sex differences were seen. These changes were remarkable in each highest dose group. The weight loss of the brain was noted at the lowest dose group of neutrons. In addition, the weight loss of the thymus, atrophy of the seminiferous tubules, and a decrease in follicles of the ovary were also noted in the higher dose groups of neutrons and gamma-rays. The degrees of these changes were larger for neutrons.
Postnatal Changes in Mice Exposed In Utero to Fast Neutrons
