WEKO3
アイテム
{"_buckets": {"deposit": "4b140c41-22a3-4801-b661-8e8970c8d692"}, "_deposit": {"created_by": 1, "id": "43361", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "43361"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00043361", "sets": ["1"]}, "author_link": ["431352", "431350", "431355", "431354", "431357", "431351", "431359", "431358", "431353", "431356"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "306", "bibliographicPageStart": "302", "bibliographicVolumeNumber": "17", "bibliographic_titles": [{"bibliographic_title": "Biological Sciences in Space"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We investigated the difference in cell-killing effect and mutation induction between carbon- and neon-ion beams in normal human cells. Carbon- and neon-ion beams were accelerated by the Riken Ring Cyclotron (RRC) at the Institute of Physical and Chemical Research in Japan. Cell-killing effect was measured as the reproductive cell death using the colony formation assay. Mutation induction at the HPRT locus was detected to measure 6-thioguanine-resistant clones. The mutation spectrum of the deletion pattern of exons of induced mutants was analyzed using the multiplex polymerase chain reaction (PCR). Cell-killing effect was almost the same between carbon- and neon-ion beams with similar linear energy transfer (LET) values, while there observed a large difference in mutation frequency. Furthermore, in the case of neon-ion beams 60% of mutants showed total deletions and 35-40% showed partial deletions, while 95-100% of carbon-ion induced mutants showed total deletions. The results suggest that different ion species may cause qualitative and quantitative difference in mutation induction even if the LET values are similar.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0914-9201", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Masao"}], "nameIdentifiers": [{"nameIdentifier": "431350", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuruoka, Chizuru"}], "nameIdentifiers": [{"nameIdentifier": "431351", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanai, Tatsuaki"}], "nameIdentifiers": [{"nameIdentifier": "431352", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "431353", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatagai, Fumio"}], "nameIdentifiers": [{"nameIdentifier": "431354", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Masami"}], "nameIdentifiers": [{"nameIdentifier": "431355", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 雅雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "431356", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鶴岡 千鶴", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "431357", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "金井 達明", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "431358", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "谷田貝 文夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "431359", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/43361", "pubdate": {"attribute_name": "公開日", "attribute_value": "2004-03-04"}, "publish_date": "2004-03-04", "publish_status": "0", "recid": "43361", "relation": {}, "relation_version_is_last": true, "title": ["Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells"], "weko_shared_id": -1}
Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells
https://repo.qst.go.jp/records/43361
https://repo.qst.go.jp/records/43361eed76178-d58d-4685-9c69-582a175fe366
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2004-03-04 | |||||
タイトル | ||||||
タイトル | Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Suzuki, Masao
× Suzuki, Masao× Tsuruoka, Chizuru× Kanai, Tatsuaki× Kato, Takeshi× Yatagai, Fumio× Watanabe, Masami× 鈴木 雅雄× 鶴岡 千鶴× 金井 達明× 谷田貝 文夫 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the difference in cell-killing effect and mutation induction between carbon- and neon-ion beams in normal human cells. Carbon- and neon-ion beams were accelerated by the Riken Ring Cyclotron (RRC) at the Institute of Physical and Chemical Research in Japan. Cell-killing effect was measured as the reproductive cell death using the colony formation assay. Mutation induction at the HPRT locus was detected to measure 6-thioguanine-resistant clones. The mutation spectrum of the deletion pattern of exons of induced mutants was analyzed using the multiplex polymerase chain reaction (PCR). Cell-killing effect was almost the same between carbon- and neon-ion beams with similar linear energy transfer (LET) values, while there observed a large difference in mutation frequency. Furthermore, in the case of neon-ion beams 60% of mutants showed total deletions and 35-40% showed partial deletions, while 95-100% of carbon-ion induced mutants showed total deletions. The results suggest that different ion species may cause qualitative and quantitative difference in mutation induction even if the LET values are similar. | |||||
書誌情報 |
Biological Sciences in Space 巻 17, 号 4, p. 302-306, 発行日 2004-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0914-9201 |